Though cholera mainly affects children in developing countries, the US is still at risk for outbreaks of this potentially lethal infection following natural disasters or terrorist attacks that disrupt access to clean water and sanitation systems. The manufacture of a safe, rapidly effective oral vaccine will be beneficial for both those in endemic areas and those in non-endemic countries.
Global Burden of Cholera
Official statistics show that global cholera cases are approximately 200,000-500,000 per year. However, current research shows that these reported figures only represent 5-10% of actual cholera cases, and it actually affects 3-5 million people and causes over 100,000 deaths per year.